PUBLICATIONS

• Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP. Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita. Nat Genet. 2019 Sep 30. doi: 10.1038/s41588-019-0502-z.

 

• Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP.Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364(6441). doi: 10.1126/science.aau0159. PubMed PMID: 31097636.

 

• Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell.2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052. PubMed PMID: 29677511; PubMed Central PMCID: PMC6061940.

 

• Zarringhalam K, Tay Y, Kulkarni P, Bester AC, Pandolfi PP, Kulkarni RV. Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach. Sci Rep. 2017 Aug 10;7(1):7755. doi: 10.1038/s41598-017-08209-1. PubMed PMID: 28798471; PubMed Central PMCID: PMC5552881.

 

• Lamm N, Maoz K, Bester AC, Im MM, Shewach DS, Karni R, Kerem B. Folate levels modulate oncogene-induced replication stress and tumorigenicity. EMBO Mol Med.2015 Sep;7(9):1138-52. doi: 10.15252/emmm.201404824. PubMed PMID: 26197802; PubMed Central PMCID: PMC4568948.

 

• Ozeri-Galai E, Tur-Sinai M, Bester AC, Kerem B. Interplay between genetic and epigenetic factors governs common fragile site instability in cancer. Cell Mol Life Sci.2014 Dec;71(23):4495-506. doi: 10.1007/s00018-014-1719-8. Epub 2014 Oct 9. Review. PubMed PMID: 25297918.

 

• Ben-David E*, Bester AC*¥, Shifman S¥, Kerem B. Transcriptional dynamics in colorectal carcinogenesis: new insights into the role of c-Myc and miR17 in benign to cancer transformation. Cancer Res. 2014 Oct 1;74(19):5532-40. doi: 10.1158/0008-5472.CAN-14-0932. Epub 2014 Aug 14. PubMed PMID: 25125661.

* These authors contributed equally to this manuscript.

¥ These authors are the corresponding authors for this manuscript.

• Oren YS, McClure ML, Rowe SM, Sorscher EJ, Bester AC, Manor M, Kerem E, Rivlin J, Zahdeh F, Mann M, Geiger T, Kerem B. The unfolded protein response affects readthrough of premature termination codons. EMBO Mol Med. 2014 May;6(5):685-701. doi: 10.1002/emmm.201303347. PubMed PMID: 24705877; PubMed Central PMCID: PMC4023889.

 

• Bester AC, Kafri M, Maoz K, Kerem B. Infection with retroviral vectors leads to perturbed DNA replication increasing vector integrations into fragile sites. Sci Rep.2013;3:2189. doi: 10.1038/srep02189. PubMed PMID: 23852038; PubMed Central PMCID: PMC3711054.

 

• Ozeri-Galai E^*, Bester AC*, Kerem B. The complex basis underlying common fragile site instability in cancer. Trends Genet. 2012 Jun;28(6):295-302. doi: 10.1016/j.tig.2012.02.006. Epub 2012 Mar 31. Review. PubMed PMID: 22465609.

*These authors contributed equally to this manuscript.

 

• Ozeri-Galai E, Lebofsky R, Rahat A, Bester AC, Bensimon A, Kerem B. Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.Mol Cell. 2011 Jul 8;43(1):122-31. doi: 10.1016/j.molcel.2011.05.019. PubMed PMID: 21726815.

 

• Bester AC, Roniger M, Oren YS, Im MM, Sarni D, Chaoat M, Bensimon A, Zamir G, Shewach DS, Kerem B. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell. 2011 Apr 29;145(3):435-46. doi: 10.1016/j.cell.2011.03.044. PubMed PMID: 21529715; PubMed Central PMCID: PMC3740329.
  1. Preview: Cell 145: 337-338(2011).
  2. Faculty of 1000 Biology, must read
  3. Top 7 in molecular biology. TheScientist, June 14, (2011).
  4. Research Highlights, Community Choice: Nature 474, 9 (2011).
  5. Research highlights: Nature Structural & Molecular Biology 18, 637 (2011)
  6. Research highlights: Nature Genetics 43, 511 (2011).
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• Schwartz M, Oren YS, Bester AC, Rahat A, Sfez R, Yitzchaik S, de Villartay JP, Kerem B.Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations. PLoS One. 2009;4(2):e4516. doi: 10.1371/journal.pone.0004516. Epub 2009 Feb 18. PubMed PMID: 19223975; PubMed Central PMCID: PMC2637976.

 

• Bester AC, Schwartz M, Schmidt M, Garrigue A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Ben-Porat N, Von Kalle C, Fischer A, Kerem B. Fragile sites are preferential targets for integrations of MLV vectors in gene therapy. Gene Ther. 2006 Jul;13(13):1057-9. doi: 10.1038/sj.gt.3302752. Epub 2006 Mar 2. PubMed PMID: 16511518.